Candy and Harvey Wasserman's relationship was developed after Maggie Gyllenhaal and David Krumholtz enjoyed working with each other on set. The writers saw their rapport and incorporated it into the show.
The title refers to the nickname once given to the block of West 42nd Street between 7th and 8th Avenues, the "Forty-Deuce," which in the 1970s and '80s was known for its high concentration of low-rent movie theaters that specialized in exploitation and pornographic films, among other things.
Actress Andrea-Rachel Parker plays "Bernice", a newly-formed prostitute that is traded to Rodney, portrayed by rapper Method Man. Parker also stars in Hulu series Wu-Tang: An American Saga" as Mama Ganja, a co-worker of Shotgun, a biographical portrayal of Method man, played by rapper Dave East.