Mom has been applauded for addressing themes of real-life issues such as alcoholism, drug addiction, teen pregnancy, problem gambling, homelessness, relapse, domestic violence, overdose, rape, obesity, stroke and has been praised for maintaining a deft balance between the humorous and darker aspects of these issues.
In Season 2 Episode 9 called "Godzilla And A Sprig Of Mint" when Christy (Anna Faris) is asked to name some of her friends she starts naming the female characters of Friends (Rachel, Phoebe and Monica). Faris had a recurring role during the final season of that series as Erica, the woman who was giving her twins to Monica for adoption.
The show's theme music is from the Overture to the opera "Ruslan and Ludmilla", which was written by the Russian composer Mikhail Glinka during the 1830s and '40s. Glinka is regarded as a founding father of Russian classical music and the Overture is still a staple in the repertoires of symphony orchestras around the world.
Mom has consistently received high ratings, with an average viewership of 11.79 million, making it the third highest rated comedy on broadcast television in the US. It is among the top 5 comedies in both adults 25-54 and adults 18-49.
Several characters share last names with players from the Oakland Raiders NFL team. Jim Plunkett (Christy, Bonnie and family) was a quarterback in the 1980s, Fred Biletnikoff (Alvin) a receiver in the 1970s and Sebastian Janikowski (Adam) a kicker in the 2000s. Also Cornerback Lester Hayes (Candace), Tight End Dave Casper (Steve) and Hall of Fame Quarterback Ken Stabler (Ray). Additionally Emily Osment plays Jody Hubbard (RB Marv Hubbard), Chris Pratt makes an appearance as Nick Banasak (RB Pete Banasak), and Rosie O'Donnell plays the part of Janine Blanda (QB, K George Blanda)
The show has received various accolades with Allison Janney (Bonnie) winning two consecutive Primetime Emmy Awards for Outstanding Supporting Actress in a Comedy Series in 2014 and 2015 and being nominated in 2016 and for Outstanding Lead Actress in a Comedy Series in 2017 and 2018.
Amy Hill, who plays Beverly, one of the tenants in the apartment building managed by Allison Janney's character, also appeared in an episode of Two and a Half Men as the receptionist in Alan's chiropractic office. She,along with Allison Janney, Emily Osment, Jaime Pressly, Sara Rue, and Missi Pyle have appeared in Two and a Half Men as well as another Chuck Lorre show "Mom".