The trivia items below may give away important plot points.
The hurricane that hits Miami is named Hurricane Laura; Dexter's mother's name was Laura Moser. When the news anchor announces that Hurricane Laura is over, it also symbolically indicates the end of Dexter's life as he knows it.
In the finale of season 4, When Dexter is talking to Arthur, he asks him if the alternative to getting caught would be to fake his death and start over somewhere else. That directly foreshadowed this episode where Dexter does just that.