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Mike & Molly's home is the same set from Roseanne (1988).
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Actress Cleo King portrays the character of Grandma to Reno Wilson's character, Officer Carl McMillan. However she is only 6 years older than Carl McMillan born August 1969 and Cleo King being born in 1962 possibly the smallest age difference between actors playing grandchild and grandparent in regular series television history.
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The show "Mike and Molly" got it's name from a bar in Champaign, Illinois called "Mike & Molly's."
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Billy Gardell and Reno Wilson had previously been police partners in Heist (2006). Billy Gardell also played Officer Hoyn on My Name Is Earl (2005).
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The name of the school where Molly teaches is Walter Payton Elementary School in the Chicago Public School System, a fictional school (although the Chicago School District did name a high school, Walter Payton College Prep, in Payton's honor). Walter Payton, an NFL Running Back with the Chicago Bears for 13 seasons, was a Chicago legend who died in 1999 at age 45 from a rare autoimmune liver illness, leaving behind a charitable philanthropic trust which distributes toys to underprivileged children and maintains a cancer and liver research fund.
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Billy Gardell and Reno Wilson are good friends in real life, and had been looking for a project they could do together when Gardell was approached about "Mike & Molly". Both agreed it was an ideal situation, and Gardell asked for Wilson to be brought onboard.
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One of the premises of the show is the characters are Chicago Cubs fans. It just so happens that the series was cancelled the same year the Cubs won the World Series for the first time since 1908, which ended a 108 year World Series drought. They were the first team in major league baseball to play three consecutive World Series and win two of them, 1907 & 1908.
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In the second episode of season 1, Molly stated that she looks like Kathy Bates in Misery (1990). On seasons 4 and 5, Kathy Bates makes a guest appearance on the show as Kay McKinnon.
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Season 4 was going to be launched on midseason, but the cancellation of 'We Are Men' moved the premiere to November 2013.
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James Burrows directed the first and last episode of the show.
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While discussing potential baby names, Carl announced that his middle name is Enoch (s3/ep4), in case Molly wants to choose that for the baby's name.
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It has been established in several episodes that Mike's personal car is an older (very) model Mitsubishi Galant with bad brakes.
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Cancelled after six seasons (December 13, 2015)
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The Season 3 finale "Mike & Molly: Windy City (2013)," originally broadcast in Canada, saw Molly reveal that she was pregnant. However, this announcement was removed from the episode when it later aired on CBS (and the subsequent DVD release) and the storyline of Molly being pregnant was abandoned in the next season. However, it was acknowledged in one episode of season four that Molly miscarried.
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