The USG Ishimura, a miner spaceship, is transporting a strange artifact called the Red Marker. In the Aegis VII colony, where the Red Marker was found, there are some suicides and murders and the people are slowly going mad. The people are being infected by something. Barrow, the foreman, finds the body of his wife having committed suicide. Barrow decides to escape the colony's madness and, taking his wife's body, goes on board the Ishimura. But something happens to Barrow's wife on board the Ishimura.
Meet Your Maker.
Did You Know?
The blonde survivor that Alissa asks whether or not she has a boyfriend is Nicole, Isaac Clarke's girlfriend from the "Dead Space" videogame, which takes place after "Downfall". See more
It is clearly seen about 18 minutes into the movie that Jen slices her throat; a large gash is shown with blood spilling out. A few moments afterwards, Barrow is seen rushing down the hallways with Jean's body in his arms. It is shown that Jen's throat has no blood - in fact, it's not even cut. See more
My name is Alissa Vincent. I may be the sole survivor. We've encountered an alien life form. They have taken over the bodies of the crew. The colony was lost. My team is dead. It is my belief that the artifact we discovered on the surface is somehow responsible. If you find this recording, the Ishimura and the artifact must be destroyed.
References Night of the Living Dead