Robert Wagner was originally cast in the Hugh Hefner role, but when the rough cut was screened for Hefner's approval, he was so amused by the film that he agreed to play himself. As a result, all of Wagner's scenes had to be scrapped and re-shot.
In the early scene at the "Abstinence Now" seminar, some of Raquel Alessi's (Cindi Whitehall's) lines were dubbed over for the movie's final release. Originally, the story she told on stage prominently featured the word "retard", referring to a baby that was born to an illegitimate mother who smoked. Due to concerns over bad press, the word was changed to "crackhead".
After Eugene awakens from his coma and first hears about horsedick.mpeg, Tucker tells him "you're so white". Both actors previously starred, wrote, and directed The Whitest Kids You Know, an uncensored sketch comedy show.
Horsedick.MPEG is based on a shock viral video known as "Mr. Hands", featuring a man named Kenneth Pinyan who was sexually penetrated by a horse. Pinyan later died from injuries after another sexual encounter with a horse.