Family Guy (1999– )
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Stewie Kills Lois 

Stewie kills Lois, and one year after her disappearance, Peter is charged with her death.


Seth MacFarlane (created by), Seth MacFarlane (developed by) | 2 more credits »


Episode cast overview, first billed only:
Seth MacFarlane ... Peter Griffin / Stewie Griffin / Brian Griffin / Glenn Quagmire / Carter Pewterschmidt / God / Kool-Aid Guy / Ringo Starr / Telegraph Sex (voice)
Alex Borstein ... Lois Griffin / Asian Hooker / Sandra Bullock (voice)
Seth Green ... Chris Griffin / Random Man (voice)
Mila Kunis ... Meg Griffin (voice)
Mike Henry ... Cleveland Brown / John Herbert / Bruce the Performance Artist (voice)
Paula Abdul ... Paula Abdul (voice)
David Boat ... Rupert (voice)
Alexandra Breckenridge ... Cancer Sufferer (voice) (as Alex Breckenridge)
Simon Cowell ... Simon Cowell (voice)
Mark Hentemann Mark Hentemann ... Male Voices / Audience Member #1 (voice)
Randy Jackson ... Randy Jackson (voice)
Phil LaMarr ... Judge (voice)
Danny Smith Danny Smith ... TV Announcer / Paul McCartney / Lawyer (voice)
Patrick Stewart ... Avery Bullock (voice)
Alec Sulkin ... Baseball Announcer #1 / Voice (voice)




Stewie kills Lois, and one year after her disappearance, Peter is charged with her death.

Plot Summary | Plot Synopsis


Animation | Comedy


TV-14 | See all certifications »

Parents Guide:

View content advisory »

Did You Know?


This episode and the following episode, with the title names reversed (Stewie Kills Lois (ep 6.4) and Lois Kills Stewie (ep 6.5)), were originally broadcast back-to-back on November 4, 2007 as a 2-parter. See more »


When Stewie shoots Lois, the number of bullet holes changes from shot to shot. See more »


Stewie Griffin: You know, Meg has really flourished since Lois was murdered.
Brian Griffin: What are you talking about? Lois' death was an accident.
Stewie Griffin: Which is what someone who pulled the perfect murder would want you to think.
Brian Griffin: What the hell are you... Stewie... did you... did you kill Lois?
Stewie Griffin: Of course I didn't, Brian.
[as he's explaining, his head turns 90 degrees]
Stewie Griffin: Remember what you said? I'm all talk. I wouldn't possibly go through with it. I'll just poop and fall asleep!
Brian Griffin: My God! You did it! You actually did it!
Stewie Griffin: [...]
See more »

Crazy Credits

At the end of this cliffhanger episode the title cards are in the same typeface used in "Star Trek: The Next Generation". The music used is from the episode "Best of Both Worlds" where Picard is transformed into Locutus of Borg. See more »


References Titanic (1997) See more »


Let's Have Another Cup of Coffee
Music and lyrics by Irving Berlin
Performed by Glenn Miller and his orchestra
See more »

User Reviews

The 100th Episode of Family Guy: Stewie Kills Lois
31 October 2007 | by MicknoSee all my reviews

Stewie Kills Louis is the 100th episode of "Family Guy" and overall it's pretty good. It had its classic Family Guy moments, and a surprising twist ending. A few days before it aired, the creator of "Family Guy" (Seth MacFarlane) had announced that in the 100th episode of this popular show there would be a death. The title of this episode tells the whole story.

In "Stewie kills Lois", Peter and Lois go on a cruise to celebrate Lois's recent birthday. Back in Rhode Island, Stewie is angry that Lois didn't take him with her on the cruise, and vows to kill Lois as soon as she comes back. Brian simply laughs at him and reminds him of all the other times in the past he said exactly the same thing, and that he will never kill Lois. Stewie is furious and is determined to prove Brian wrong, which sets out the plot for the rest of the episode.

This was a highly entertaining "Family Guy" episode. It was filled with humor and contained a surprising twist ending which sets the scene for the next episode. It's definitely worth viewing, a must-see for all die hard Family Guy fans.


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Release Date:

4 November 2007 (USA) See more »

Company Credits

Show more on IMDbPro »

Technical Specs


Sound Mix:

Dolby (presented in)



Aspect Ratio:

1.33 : 1
See full technical specs »

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