As of 2016, "Heads Up!," "Never Have I Ever," "Learning Accents" and "True or False" are some of the games host Ellen DeGeneres played with her guests. "What's in the Box?," "Let's Make a Trade," "Blindfolded Musical Chairs," "Fast Fingers of Fate" and "Epic or Fail" are some of the games she had audience members play.
Occasionally, the show got serious and rather emotional and dealt with serious issues and matters that have happened that affected host Ellen DeGeneres personally. In one show, DeGeneres broke down live on the set over a puppy she had given way and in other shows, she addressed the tragic deaths of homosexual teenagers and talked about a difficult day she had.
On one occasion, she showed a video of a cute baby goat jumping up and down repeatedly (as baby goats always do) and while the viewers were watching the video, Ellen added a useful bit of guideline, saying "Look at that baby goat. It's jumping."