MacGyver and his young Chinese friend are again at odds with Chinese criminals over labor regulations. During his investigation, Mac is helped by a photojournalist biker named Sam. It turns out that Sam has more than just a passing interest in MacGyver - he believes that MacGyver is his father!
A prophecy predicts that a resourceful man (MacGyver) from the west follows another man (Jack Dalton) to an Ammukash Valley that is supposed to hold the Fountain of Youth. The Valley is, in MacGyver's own words, "Kabulstan, a very hostile third world country that does not like strangers". The prophecy says that the resourceful man has something to do with the destiny of the people of the valley.