A woman hires Kimble to be the caretaker of her brother who was disabled in a car accident. Her boyfriend wants her to run away with him along with her brother's insurance money. Kimble becomes the unwitting patsy in his scheme.
A young woman (Katherine Crawford), desperate to be free of her mother's manipulating control, plans to marry a boy her mother doesn't approve of. Kimble (David Janssen) tries to help but the girl's other suitor threatens to expose him if he interferes.
A police roadblock, including Lt. Gerard, causes Kimble to escape cross country into an area populated with moonshiners. With Gerard in hot pursuit, they're both caught, and Kimble must defend Gerard to keep him from being hanged.
A small town is on edge because two women have been murdered. Kimble (David Janssen) is stopped by a group of vigilantes who suspect any stranger. He escapes and hides in an abandoned building, where he is helped by a young naive woman (June Harding).
Kimble hides in a home for the blind after his likeness appears on television. In the home resides former police chief Brady, blinded in the line of duty and who wishes to prove the incompetence of the current chief by nabbing Kimble.
After falling in with two other escaped fugitives Kimble has to accompany them when they force themselves into the home of a woman and her mother. He then has to figure a way out while also trying to protect the women.
The son of a rich landowner comes back home to take over the business after his father's accidental death. The son's return brings resentment from some of the workers who believe he's responsible for a young woman's death.
Not knowing the cops are close behind him, Kimble (David Janssen) gets a job at Jungle Land, a small-town animal attraction that is in financial trouble. One of Jungle Land's partners (Steve Forrest) hatches a plan to have Kimble captured on the premises for the publicity.
After being stabbed while rescuing a woman from her attacker, Kimble is taken to the nearest infirmary, located inside a prison. One of the inmates threatens to expose Kimble if he doesn't help in a drug smuggling operation.
A woman with whom Kimble was dining becomes angry when he tells her he must leave town. She disappears and is found roughed up but alive. Kimble knows she must tell police he did not abduct her in order to save him from being arrested.
After being snubbed by local police, a small-time mentalist sees his big break in his crystal ball when he spies Dr. Kimble toiling at a gas station. Instead of just turning in the escapee, Sal Mitchell plans to boost his career by having his beautiful, blonde wife Joan Mitchell lure the physician 200 miles away to Lincoln, Illinois, after predicting where Kimble will be. Joan entices Kimble by claiming that, en route from Chicago to Southern Illinois, she noticed a cruel-looking one-armed man working near a statue of Abraham Lincoln. Kimble gets an urge for going, ...
A man comes forward and admits to having seen the one-armed man running from the house the night of Helen Kimble's murder. This gives Richard Kimble hope of another trial which could clear his name. Will this man be willing to testify; and will his testimony be enough?
A favorite son, now a huge success, comes back to his hometown to start a new operation. At first everyone seems to be happy he's back, but simmering jealousies come to the front when someone threatens to kill him.
After injuring his ankle while running from the police Kimble winds up in the care of a natural medicine practitioner. Kimble believes another patient of his is seriously ill but is unsure how to save her.
Kimble's joined on the run by Lt. Gerard's wife, who's had it with being no. 2 to a phantom. Kimble stumbles, signing his own name on a time-sheet, which sets off a manhunt, while residents battle a flood. Gerard (Barry Morse) drags his wife off of their vacation to join the hounds. With many roads out of the Midwest city under water, Marie Gerard (Barbara Rush) and Kimble (David Janssen) end up on the same Eastbound bus.
Stranded in an abandoned town and awaiting help, the blind Mrs. Gerard (Barbara Rush) realizes she is with Kimble (David Janssen). With her husband on the way, she delays Kimble's departure, hoping his capture will end her husband's obsession and save her marriage.
The owner of a warehouse distributorship threatens to report Kimble to the police if he doesn't stay away from his sister. He has no interest in her but when she kidnaps a small boy he must choose between saving the boy or himself.
After three police officers are murdered Kimble (David Janssen), the new stranger in town, becomes the obvious suspect. His situation is complicated by his boss (William Shatner), a former cop who suffers from a mysterious psychiatric problem.
Kimble is arrested in a play arrest, which soon turns real at an annual town celebration in which Marshal Judd tries to hide him from Lt. Gerard, with the aid of his much put off fiancée Laura, to collect a suspected reward for Kimball's capture.
While running from the police, Kimble "borrows" another man's wallet to pay for a train ticket. He goes to great lengths to return the wallet and money but in so doing he sees the man murdered and becomes the chief suspect in his death.
At an off-season motel a woman turns to Kimble for help with her son, who is an unusually bright but troubled child. Kimble helps the boy so much that when he has to run from the local sheriff, the boy follows after, imperiling them both.