After escaping a police dragnet in Lincoln City, Nevada, Kimble comes upon Sister Veronica and her broken-down truck on a road in the desert hills. She convinces him to accompany her on her trip to Sacramento, despite his protests that he's heading in another direction.
A man helps Kimble escapes from a Sheriff and is wounded. As he nurses him, he discovers the man is tortured by a very guilty conscience in connection with a murder rap he was acquitted of months before.
Richard Kimble meets an old army buddy who saved his life during an explosion in the Korean War, and got badly disfigured in the process. Filled with bitterness, this ex army person plots to either disfigure Kimble, or kill him.
A dragnet traps Dr. Kimble to within a few city blocks while hides out in a house owned by two men. One of the men believes Kimble is innocent and the other does not, and wants to turn him over to the police.
A private detective hired by Dr. Kimble's defense attorney has found the one-armed man. The attorney's daughter meets Kimble to help him but ultimately hopes to run off with him and start a new life together.
Kimble helps Lucey when her car won't start. The next morning, she's accused of murdering a man at the exact time that she was with Kimble. Kimble wants to help but knows it's too dangerous to stay and testify on her behalf at the inquest.
The Cheyney's, bitter over Harold being hit by one of Pryor's trucks without receiving proper compensation, plans to kidnap Pryor for ransom but instead kidnaps Kimble working as Pryor's gardener thinking Kimble is Pryor.
When someone develops symptoms of the plague Kimble is forced into a difficult position: should he report it and risk getting caught or ensure his safety by leaving town and ignoring a potential epidemic.
When robbers shoot two policemen, Kimble's nearby, so he hides in orphanage's station wagon to get away from the dragnet. Two orphans he met beforehand promise they'll alibi him, but Sean Dubose, another state ward, plans to use Kimble in his own escape - fearing he'll be shipped to an Illinois juvenile prison soon. Sean's embittered from being abandoned by his alcoholic uncle, after Sean's parents' deaths. Kimble is torn between an immediate, but risky daylight escape, or helping the troublesome boy.
Kimble, on the run again, finds himself stranded on a broken down bus on a remote mountain road. The passengers discover Kimble's true identity and one of them, armed with a gun, is determined to turn him in to the police.
Kimble is photographed with a Congresswoman during her inspection of a military construction project. After they are trapped underground, Lt. Gerard arrives on the scene, confident that he has finally caught Kimble.
Kimble is riding with a man named Hanes who is driving back to his hometown. When Hanes starts a fight, the sheriff arrests them both, as he recognizes Kimble as a wanted man. A troubled youth named Tad plans to help Kimble escape.
A singer (Janis Paige), who bears a strong resemblance to Kimble's (David Janssen) dead wife, arrives at a club he works at and offends everyone with her boorish behavior. He eventually discovers her rudeness is due to a personal and tragic secret.