After being on the run for 6 months, Richard Kimble falls in love with a beautiful woman who has a young son. She also has a physically abusive, estranged husband, that wants Kimble out of town, or dead.
After saving a busload of kids in an accident, Kimble is knocked unconscious and later identified as a fugitive. Gerard comes to this Massachusetts town to extradite him back to Indiana, much to the dismay of the town's grateful residents.
Working at a remote construction site, Dr. Kimble tries protect a coworker with a low I.Q. from being lynched when the caring married woman who's been teaching him to read, is assaulted by an unknown attacker.
A beautiful airline stewardess badly injuries Kimble in a traffic accident and in his delirium he admits who he is and she helps him. In turn, Kimble helps her realize the married man she's dating is not right for her.
After escaping a police dragnet in Lincoln City, Nevada, Kimble comes upon Sister Veronica and her broken-down truck on a road in the desert hills. She convinces him to accompany her on her trip to Sacramento, despite his protests that he's heading in another direction.
A man helps Kimble escapes from a Sheriff and is wounded. As he nurses him, he discovers the man is tortured by a very guilty conscience in connection with a murder rap he was acquitted of months before.
Richard Kimble meets an old army buddy who saved his life during an explosion in the Korean War, and got badly disfigured in the process. Filled with bitterness, this ex army person plots to either disfigure Kimble, or kill him.
A dragnet traps Dr. Kimble to within a few city blocks while hides out in a house owned by two men. One of the men believes Kimble is innocent and the other does not, and wants to turn him over to the police.