The drovers hear an owl at night - the human type. As they search around the camp Favor finds a young woman. Although dirty, they soon discover she is white but out of her mind. The Cheyenne want to kill as they believe she is a witch.
After a stampede Mushy and Wishbone go to town for fresh supplies. When Wishbone is able to stop Amie Claybank from harassing a vendor, her brothers decide he is the man for her. Back at camp, Mushy says Wishbone disappeared.
Wishbone develops a mysterious blindness after a scary encounter with a dangerous cliff and an innocuous fall. A doctor finds no physical reason for the blindness. A psychological reaction to childhood trauma is suspected as the cause.
Rowdy and Jim looking for strays, return with five - four bulls and a lost Scottish lady returning to Scotland. She says her husband stole her inheritance so she is taking her remaining items home with her plus a surprise for all.
The drovers find a Sergeant carrying a dead soldier in Apache country. They send for the Army learning the Apaches are due 200 cattle to keep a treaty. A renegade stands in the way. Favor, Jim, and Wishbone help try to deliver the cattle.
After a tornado scatters the herd, they are a 100 head short. They learn a man running an orphanage sold them to the local banker. Realizing the banker is the guilty party, Favor decides to teach him a lesson and recover some of his money.
Straw Coleman is caught trying to steal a horse and saddle while in chains. The drovers are shocked when Wishbone pulls a gun on them and helps Coleman escape. Favor and Mushy go after them to find why Wishbone has strayed.
During a rainstorm the men see a man who disappears but eventually comes into camp - dry. His name is Michob - the same as the wanderer in a book of legends owned by Wishbone. When bad things occur, some of the men think he is a jinx.
A Zebulon vigilante group takes Johnny Larkin away for murder. Favor follows to protect Johnny. However, Johnny is hanged and Favor is horsewhipped. Favor returns there alone with revenge on his mind looking for the man called the Major.
Favor visits an Army camp building a dam to ask for a delay to move the herd. He finds a childhood friend who asks him to stay for dinner with her and her husband who is in charge. He gets the meal and a charge of murder for killing a Lt.
After a rain storm wipes out the wagons, Favor goes to town to cash a bank draft and buy supplies. Favor's friend the banker wants to prove he is a man so he tricks Favor into trading jobs so he can prove to his overbearing wife his point.
Everything is going wrong on the trail. Men are being killed and injured, the herd is late, a river is flooding ahead and Kiowa Indians are a threat. A massive wild bull is distracting the herd and a reckless drover adds to the problems.
The town's richest and most popular man is convicted and sentenced to be hung for the revenge murder of his son's killer. He is undaunted by this because he is counting on no one in town be willing to act as executioner.
When Wishbone and Mushy realize Hannibal is not safe they try to help. They are brought back tied up while Hannibal is tarred and feathered. Hannibal returns to Deadhorse and the men want to help him against Favor's better judgment.
An attractive woman collapses near camp due to exhaustion. After recovering she and Rowdy recognize each other. She is happy to see him but Rowdy is not so happy to see her. She eventually reveals she is on the run for killing a sheriff.
Sgt Turner (William Marshall) is a fugitive from the Army. On the lam, he meets Rowdy and steals his horse. But because he spared Rowdy's life, when Rowdy captures him, Rowdy gives him work in the trail drive. Eventually, the solders pursuing Turner finally capture him. The Sergeant is one of the black "Buffalo Soldiers," who are keen on proving their worth to the skeptical army. The white Captain son of a General has been guilty of certain past offenses, and so is put in charge of the black outfit to prove his worth as well. The problem had been that the Captain has ...
Hey Soos is forced to drink Peyote juice by Indians. He has hallucinations but before they harm him further an Indian girl takes him to the camp where he recovers. Drover Mister Brothers has been looking for this band of Indians for years.
Yates and Favor argue over giving the drovers time off but Favor has a herd lined up to leave the next day. Rowdy quits but on Favor's word is offered a herd of his own. He vows to beat Favor but will skill or luck be the deciding factor?
When Favor hits a man looking for a job, the man hits a fence killing him. Favor is faced with several men wanting revenge at an inquest and the man's young and poor but pretty widow with kids wanting Favor to take her with him.
Favor hears Piney Kinney wants to join the herd thinking it will solve his need for drovers. However, Piney who lost his herd and most of his ranch, is working with a gang to rob the bank and use Favor's herd as cover for their escape.
Favor sees his herd destroyed after he takes a calculated risk in taking a dangerous short cut to get the herd to market ahead of a rival. Favor and the owners have to decide if he is up to bossing another herd.
At trails end, Mushy is embarrassed and denounced by Favor for being conned out of the drive's wagons and supplies by a band of Gypsies. Dejected, Mushy wanders off alone in the desert to be followed by Favor and Rowdy.
Storied hired gun Gurd stalks an Hispanic cattleman, while Gil's drovers join the Don's peasants to celebrate. Gurd's young wife pleads with him to drop the assignment, & retire to her family plantation, but the aging Gurd's reputation won't let him, so she seeks Gil's help.
Damon is broke and needs workers to finish his railroad into Oxford. The 28 men on Favor's crew are the ticket to do the work. Damon concocts a fight with the drovers while Favor is charged with abducting his girlfriend to trap them.
Favor breaks out of jail and gets the unpaid railroad workers to demand their jobs back by lying to them that Damon has had their pay money all along. A workers battle is averted with a first fight between Favor and Damon.
A fugitive convinces Rowdy to bring him to the sheriff and hand over the reward to his wife. But the fugitive is murdered on the way to the sheriff, no wife can be found, and three friends of the fugitive are out to kill Rowdy.
When a officer dies, Cpl. Dasovik is forced to take over the mission but he has no control over the men. The men pick up Favor when they take some of his cattle. Dasovik soon learns he is alone but he is determined to carry out his orders.
Mathew Brady's ex-assistant uses the drovers as his models, so Gil's thrilled to let the frontier paparazzo go, to snap pix of Shoshone, who Gil knows have moved on. Because Rowdy let lens-man Taylor Dickson subvert the drive, Gil orders his ramrod to accompany the grandiose photojournalist on the bogus shoot. But instead of a nice empty canyon, the mismatched pair run into the Bad Skin Gang, a fearsome collection of under-publicized killers, on a rendezvous to divvy up the loot from a huge bank heist.
The drive reaches Junction City so the men are ready to blow off steam. They want hotel rooms, good food, and baths. Their reception in Junction City is icy at best including the livery stable and Favor seems to be ignoring their plight.