Backwoods Amy Jo Jennings arrives in LA to start a singing career. She is spotted by an agent who signs the naive girl to a contract. In reality she is a wealthy target the agent takes advantage of. When he is killed, she is charged.
Lona Upton is tired of hearing her half-sister memorialize her dead husband so when Maxine Nichols arrives to return Lona's purse, she takes in Maxine as a friend. After Maxine steals a necklace and is murdered, Lona is charged with it.
Lucille Forrest returns home after a year in Europe. Her husband died a year earlier and her son was killed before that. She believes her son was murdered and wants revenge. However, she is charged with killing the man she thinks did it.
Clyde Darrell is a young rising accountant at a company where the CEO's secretary has fallen in love with him. When she learns Clyde loves the niece of the CEO, she turns on him. After they have argued, she is found murdered.
While in Hawaii to check on property for a hotel development, Perry is asked to help Anona Gilbert, who owns a critical piece of property. Her fiancé, who is involved in a scheme involving the land, breaks their engagement and is murdered.
Betty Kaster is offered the chance to live with her professor and his wife, who is recovering from an accident. She becomes suspicious that he may try to harm his wife who is set to inherit $2,000,000. When he is murdered, she is charged.
Larry Germaine, A.D.A. to Burger, has a girl friend with expensive tastes. She is disliked by his mother and becomes a tool to make it look like Larry is messing with a legal case. He is seen over her body stabbed with his mother's prop.
Italian Paulo Porro is seeing the sites and getting around by visiting Italian families. He says he is a friend of the family from Italy. He visits the Bacio family which stirs up a family feud. The elder Bacio is killed and he is charged.
Reggie Lansfield is an aspiring actress Paul meets. She is game for stunts that will get her recognized so she is game to fill in for a famous woman swimmer who is too ill to swim. The stunt blows up with the woman killed and her charged.
A frustrated Helen Kendall is living with her Aunt Matilda. She receives a call one night from a man claiming to be Matilda's husband, who has been missing for 10 years. Perry goes with her to meet him but they find another man - dead.
Danny Talbert, a LA cop, resigns when a mobster he is investigating contacts his family after Danny's dad dies. Danny's brother, Carl, works in his club and has been in trouble before. Danny is seen by Perry leaving the dead man's cabin.
Peter Warren owns a novelty company and is divorcing his wife, who has developed a gambling habit. She becomes involved in a scheme to pass chips at Nevada casinos with evidence Peter made them. When she is murdered, Peter is charged.
Herbie Cornwall is a retired baseball player who is now working as a shoe insert salesman and not doing well while his gorgeous wife is an accountant at a store. After a fire in her office, she is murdered and her husband is charged.
Perry helps Josephine Kempton after Della buys the diary of a girl who committed suicide. Her ex-boss has been telling people she is a thief so she sued. Perry has to rescue her from a gorilla trapping her with her dead boss.
Ward Toyama is approached by a man claiming to be a government agent asking Ward to use his father's export business to help in a secret project. Ward comes to find the man is a first mate on a ship. When he is murdered, Ward is charged.
Dorrie Ambler breaks into Perry's office so he can verify who she is. She won't give details but says she is mixed up in some scheme. Della spots a gun in her purse. When the man who hired her is killed, she is charged. But, who is she?
Carla Chaney is in jail awaiting her trial for murder. She has fired or lost multiple attorneys so Perry is given her case. She tells him about proof she didn't commit the murder but even Perry has a hard time believing her story.
A fortune teller tells Pat Keane that she will get married but it will end tragically. She later marries her boss, Max Armstead, a client and good friend of Mason's. However, a few weeks later, Max dies from an apparent case of poisoning.
Candy Queen Claire Armstrong is in the midst of life changing events. She fires the man who made her business and falls for a gambler she trusts - too much. When her secret recipe is stolen, a casino owner is killed and she is charged.
Van Fowler is an instructor at Perry's alma mater. He is working on his PhD with Dr. Stuart Logan. Logan is taking advantage of Van by claiming credit for their combined work. When Logan is found dead with Van by the body, he is charged.
Diana Carter is assisted from the water after stealing a message in a bottle from her dead aunt's home. She believes the man her aunt married murdered her. Perry must first defend her for theft but when the man is killed, she is charged.
Perry Mason is called in to investigate why an insurance company is near bankruptcy due to excessive claims. He calls in a claimant who appears to be healthy but dies when forced to come in for an exam, putting Perry in the hot seat.
Lucas Tolliver asks Perry for a will for his wife-to-be, which seems odd. When a dating service contacts Perry about Lucas, Perry looks deeper into his history. Lucas isn't what he says he is and is blamed when his new wife is killed.
Wealthy Ellen Payne is the primary owner of the Wildcats football team. Her husband, Burt, owns ten percent. He was a successful college player but is now a drunk gambler who causes grief for everyone. When he is killed, she is charged.
Perry successfully defends Louise Selff when she is charged with killing her husband. The pressure of the trial has affected Louise so when strange things happen, it appears she killed him again when it turns out he was still alive.
Pete Griston is a race car driver in a new partnership. After the fact, he asked Perry to look it over and he discovers problems. When Pete has an accident in a test car, it starts a series of events leading to the murder of his partner.
Susan Wolfe is beaten within an inch of her life while her neighbors sit and do nothing. Her overprotective brother, Dave, an L.A. police detective, runs to the apartment to check on his sister and is knocked unconscious as a man is killed.
Perry is asked to help retrieve the granddaughter of a scientist from East Germany, which wants him back. During the negotiations, a go between is murdered with the wife of the scientist charged so Perry defends her in East Germany.
Dr. Todd Meade works for a company developing a new secret process. The company hires Paul to ensure security for a meeting but the details leak. Meade had worked for the competition so, when a man is killed in his lab, he is charged.
Victor Montalvo picks up a young lady hitchhiking which results in being blackmailed by her. He is part owner of a storied men's club but a new co-owner is changing the format. When he is killed, Victor is charged and she is a key witness.