Virginia Trent is having a bad day. Her Aunt is shoplifting, her Uncle George is missing, and diamonds are missing from George's business. When her aunt is charged with murdering an old friend who is a diamond agent, Perry is needed.
Linda Blake arrives in Ladera looking for her father only to find he has been dead for several years. His death occurred with suspicions that Charles Lambert killed him. When his alibi, Floyd Grant, is murdered, Linda is charged.
Laura Hewes' divorce is nearly complete. After an experiment in his class, her husband learns she is in town staying with another couple. His problems compound due to a charge of plagiarism. When he is murdered, Laura is charged.
After the death of her husband and partner, Joe Doyle, Constant Doyle takes on a case involving a young man who knew her husband. Constant asks for Perry's help and he suggests she hire the Paul Drake Detective agency to aid in the case.
Janice Norland turns to her law professor when she thinks she killed a man. When there is no body, they assume all is okay but she is soon the target of blackmail. When the man turns up dead, she is charged so the professor defends her.
Elihu Laban, a political refuge from the Balkans, hopes to obtain the papers from a leader who supposedly committed suicide. He and a group put together a plan using a former member of the OSS. When the seller is killed, he is charged.
Hollis Wilburn's main problem is deciding between two beaus who are also after a franchise from her uncle. Her problems grow when her uncle is first blackmailed and then murdered. Being in line to inherit his estate, she is charged.
Sandra Keller has agreed to sell her grandfather's orange orchard to a developer for mall parking. When the grandfather changes his mind, the deal is off but a lot of people will be hurt. When the developer is shot, she is charged.
Trevor Harris has returned home after 10 years as his wife is dying and he wants to ensure his children have a good home with Jill Garson instead of family patriarch Edgar Thorne. However, when Thorne is shot, Harris is charged.
Eva Belter is caught in a photo leaving an illegal gambling club with a politician. Fearing she will be blackmailed, she asks Perry for help but she seems dishonest and tries to incriminate Perry. Her murdered husband is the blackmailer.
Roy Comstock is handling the finances in a real estate deal with Peter Brent. However, his divorce has distracted him so Peter is worried about losing his land. Roy supposedly commits suicide but Peter is charged with his murder.
Dwight Garrett is the absent minded brains of a floundering high tech partnership with Austin Lloyd who is more of a con-artist. In an attempt to save himself, Lloyd tries to frame Garrett for his murder but the murder becomes real.
Sculptor John Kenyon returns from Greece with a beautiful model and her mother. Kenyon becomes very irritated with the both of them when the mother interferes with his attempts to court the model. When the mother is killed, he is charged.
Margaret Layton is deeply worried that ex-husband and author Richard Harris will publish a trashy novel because of its affect on their daughters. When she visits him, she is overheard threatening to kill him and fires a gun in his desk.
Nelson Tarr bought a small town radio station due to a recommendation from his friend, Andrea Walden, who is married to the owner. However, her husband believes the rumors about her infidelity so when he is murdered, Nelson is charged.
Judge Daniel Redmond has been nominated to run for Lt. Governor due to his high level of respect. However, he soon finds himself being forced to turn it down due to an accusation of fraud and murdering the witness against him.
John Brooks arrives at the elderly Stone sisters' home saying he knew a nephew who was declared illegitimate as a youth. Due to his recall of facts they think he is really their nephew. Ernest Stone is murdered in a tangled web of deceit.
Sylvia Thompson works with a shady manager at a truck depot plus takes care of a young boy and her derelict brother. A robbery attempt followed by a murder at the depot plus the books showing possible theft has Sylvia charged with murder.
Called in by Banning Grant, Perry learns that con artists have been selling phony gold mines. To find out who's responsible, Paul disguises himself as a prospector. When a local is murdered, Perry solves the case during a coroner's inquest.
In a very rare occurrence, Perry Mason loses a case when Janice Barton is convicted of murdering her aunt and is subsequently sentenced to death. After the verdict, Perry still investigates to try to find the real killer among the heirs.
Dr. Aaron Stuart runs a prep school but, lately, he is running into a string of problems at the school that endanger its future. Eventually, he finds that his friend, Tobin Wade, is the cause. Stuart is accused of killing Wade - twice.
Maxine Lindsay, aspiring artist and model but naive, becomes embroiled in a law suit about whether a painting is a fake. She repeats the comments of Colin Durant about the painting. Durant is found shot in her shower, so she is charged.
Encyclopedia saleswoman Gwynn Elston has moved in with her friend, Nell Grimes, and her new husband Felton. Gwynn spots a picture in a customer's home and realizes Felton is a bigamist. When Felton is found dead, Gwynn is the prime suspect.
Juli Eng is in Hong Kong after her grandfather's death who had left her a small fortune in diamonds but they are missing. She trails two men by ship to San Francisco where she is caught leaving the office of one them who is stabbed.
Before a woman dies, she leaves a certified check for $1,000,000 to her nurse which the family and their lawyer try to hide and contest. Perry is hired to obtain the check and then defend her daughter who is charged with killing the lawyer.
Young Tim Balfour has returned to live with his grandfather after his parents were killed in Italy. Tim Sr. has high hopes for grandson but Tim seems to have fallen in with a hoodlum who blackmails him. In a fight, Tim's gun goes off.
Grover Johnson and his wife Eula have a rural ranch with a big mortgage. Eula wants to leave but no one wants to pay enough to make it worthwhile to sell until a rich Texan says it is what he wants. When Eula is killed, Grover is charged.
Todd Baylor has a chance to inherit half of his father's chain of stores with his brother Martin. His chance depends on an exclusive dress brand but Martin spoils his plans. When Todd goes to confront Martin, Martin is stabbed to death.