Janice Wainwright is a dedicated secretary to Morley Theilman who becomes concerned when she learns he is being blackmailed. Perry advises her to follow through with her instructions but it results in her being charged with his murder.
For decades two branches of the Faraday family have quarreled about which branch of the family should control it. Philip Andrews, engaged to one of the have nots, is charged with murder after already being accused of fraud in the case.
Axel Norstaad is a Dane who has built a furniture business around old world craftsmanship. He is fulfilling his dream to sell the shop and using the proceeds to build a children's hospital. However, the buyer is a con man who is murdered.
A dazed woman found in a park in a raincoat says she has amnesia but her story makes no sense. She supposedly eloped with a man who is ultimately found dead in the same park. When she is charged, Perry has to dig deep to find the truth.
Peter Gregson's aunt is murdered after she investigates a company leak that may involve Peter's old secretary, Karen Ross. Karen travels to San Francisco to see the aunt and, ultimately, is charged with her murder due to pen pal letters.
Naïve secretary Susan Fisher, working overtime, tries to help her boss' employer who comes to town to check the books but digs herself deeper into trouble. She is charged with murder when another company employee is found dead.
Mike Preston was crippled in an oil well accident he blames on Hugh Jamison who he believes also stole $100,000. He and his partner, Harlow Phipps, set a devious trap for Jamison but when Phipps is murdered, it is Preston who is charged.
Pete Manders is given a chance to buy the cartoon strip he works on for only $10,000. However, when he learns it is the booby prize for having his girlfriend leave with the seller, he is enraged and charged when the seller is murdered.
Ted Chase appears to those around him to be losing his grip on reality. His first wife committed suicide and his second wife is destroying his life but he can't divorce her due to a prenup. When she is murdered, he is charged.
Mitch Heller is having emotional problems doing his job as a test astronaut at a private company. The problems become worse when a new man taking over is the general who fired Heller from the Mercury program. Heller is charged with murder.
Perry and Della find a baby in his office leading Della to be a mom and Perry trying to find the mother. He finds another man is also trying to sell information about the baby. When he is found dead, the mother looks to be guilty.
Gus Dalgran has been acting strangely and his business is suffering from someone embezzling. As things spiral out of his control, his nephew decides to have him declared incompetent. When the nephew is murdered, Gus is charged.
A new actress takes over the part of Juliet in a theater company's L.A. show, upsetting the members. Steve Brock is especially upset when his girlfriend loses the part. He is charged when the theater company owner is killed after a fight scene with him.
Herbert Simms wants to be a screenwriter instead of a pharmacist. When his script is stolen by an unscrupulous producer, he steals his script back. When he tries to put it back, he stumbles into the producer's dead body and is charged.
Merle Telford is nearly 21 but has the personality of a youngster due to her overbearing guardian's wife. Merle plans to elope after her birthday but the plans go askew when the wife is murdered and diamonds are stolen. Merle is charged.
Demure Ellen Carter works at a relative's bookstore. When a book is found missing, he fires Ellen who is concerned she might be arrested. During a visit with him, Perry notices a first edition. When the owner is murdered, Ellen is charged.
Joane Proctor and her boyfriend are concerned what will happen to a home for disabled children when Carleton Gage dies. When they find one of the heirs dead, the boyfriend concocts an idea that backfires with Joane is charged with murder.
Jimmy West believes he has a great fighter but when Tod Richards takes over the fighter's contract and hires Jimmy as trainer, Jimmy doesn't realize what he walked into. Jimmy is in the middle of a blackmail scheme and charged with murder.
Perry's friend Beth Sandover is in a strained marriage so she asks Perry for help. When the woman who took her job is murdered, she is charged as her husband tries to preserve the $201,000 he embezzled from the company where they worked.
Lt. Andy Anderson has a cousin who is moving from the beat to a patrol car partnered with Andy's old friend. The friend is killed when they respond to burglary. When the security guard is killed later, Andy's cousin is charged.
Damion White married an actress who has an offer to return to work that involves a great song. However, she recognizes the song which has been plagiarized multiple times. Her husband is one of those involved and is charged with murder.
Merchant seaman Harry Fothergill arrives in the U.S. with his mate Dickie to visit Dickie's brother and his family. Broke Dickie creates a will leaving a small fortune to Harry and his niece. When Dickie is murdered, Harry is charged.
John Gregory is caught in a trap when his mobster brother escapes and wants the money he put in a trust fund for his daughter. At the same time the manager of the trust fund tries to blackmail Gregory about it and is murdered.
Della is on the hook to Perry for $25,000 but more importantly may go to prison for helping a friend charged with murder who was being blackmailed. Perry must not only prove his client but his trusted secretary innocent as well.
On vacation, Perry decides to help Jane Wardman, who had been kind to him. She is a high school teacher and widow accused of inappropriate behavior with some of her senior students. With the whole town against her, only Perry believes her.
Jennifer Wakely is upset her uncle sold her prize horse after her dad died. Given a chance to get him back, she is interrupted by the man who bought the horse. Right after their run in, he is found dead killed by the tool she used.
Maureen Thomas is contacted by Burt Renshaw who believes he can put her in contact with the mother who abandoned her. An inheritance is involved and James Grove has found another Maureen. When Renshaw is murdered, Maureen Thomas is charged.