Cheyenne comes to the aid of a woman but finds she has double-crossed him. He tracks her down finding her a owner of a herd of cattle being driven to Kansas. He joins drive as a hand but his expertise may bring him a big payday.
Cheyenne is asked to winter in the north with a herd of cattle over the winter with two men until the owner returns. One man quits and Cheyenne runs off the other one who is the foreman after he attacks a neighbor's wife in her cabin.
During a fur trapping trip Cheyenne joins with old Hoot Hollister who plans to return to St. Louis to marry his girlfriend. While on a riverboat to St. Louis, he and Cheyenne get mixed up with a teacher and crooked gamblers.
Cheyenne's life is saved by a marshal who hires him as a deputy. The marshal is headed to the town of South Ford to arrest a man wanted for murder in Kansas. The reception they receive is chilly with Cheyenne questioning his decision.
Cheyenne is sent to investigate cattle rustling but upon arrival is told it has been solved. However, when he hears who was caught, he decides to investigate further while renewing a friendship with the lawman who trained him.
Cheyenne travels to a border town to join Joe Baker who has a business proposition to capture wild mustangs south of the border. Joe is sick but the backer and his wife are still game. Cheyenne has to worry about Indians and the wife.
Cheyenne is asked by Amarillo Ames to help drive his herd to Dodge City and take over if he dies but he doesn't want to tell the men or his daughter why. Ames dies so Cheyenne is forced to take over by force as he overcomes multiple foes.
Cheyenne rides into Stagge City (pop. 407) and is promptly arrested on trumped-up vagrant charges. After a "trial" lasting less then a minute, he's sentenced to 90 days hard-labor at the nearby silver mine - owned by Stagge.
Cheyenne is escorting a bride and $5000 to his boss. He meets a friend who works now for the railroad who tells Cheyenne a group of young bandits are robbing trains. They strike the train but their goal is more than robbing it.
Arrested and accused of robbery in Lone Butte, Cheyenne escapes to clear his name. The only clues he has are the location of the gang's well-guarded hideout and that the killer was wearing an unusual gold lion's head belt buckle.
Army scout Cheyenne is court-martialed for cowardice when he wants to abandon Army horses the Army needs to raiders who always know where to strike. The post commander is frustrated as is his wife who wants to return back east.
Cheyenne on an Army task is chased by the Sioux. He wounds a miner so he stays to help the miner and his wife. Three men wanted for selling faulty guns to the Sioux arrive with eyes for the wife and the gold although the Sioux threaten.
Cheyenne works for Charley Dolan who is given 24 hours to vacate his property. A gang run by Len Garth is forcing people off their land. He burns the newspaper office killing the owner. Dolan offers money to rebuild the paper.
Cheyenne brings a body into town killed in a strange way. The townspeople suspect Cheyenne is part of a rustler gang. While Cheyenne is hunting for the killer, a girl's jealous boyfriend is hunting Cheyenne thinking he killed his brother.
His gear stolen, Cheyenne follows the thief and killer to a small town. The outlaw has stopped there to see the sheriff - his father. The sheriff resigns so Cheyenne takes the job and falls for a girl who's father was the sheriff.
Cheyenne tries to help a young man with a younger sister and brother and a troubled history. Sadly, Cheyenne who is looking for his friend finds proof that the young man committed a serious crime involving Cheyenne's missing friend.
Cheyenne is given the deed to a livery stable worth $3000 in Gunsight to repay a $1200 debt which sounds like a good deal. Unbeknownst to Cheyenne a $30 weekly protection payment to the Gerrard gang goes along with the stable.
Cheyenne interrupts a stagecoach attack but when it crashes he is left to take care of the lone survivor - a baby. Cheyenne learns that a land grabber murdered to get his claim, then Cheyenne must protect the dead man's heir - the baby.
Looking for a job, Cheyenne rides into town and is caught up in a fight and witnesses a bank holdup. Deputized he goes after the robber, finds him but is conflicted when the fugitive saves him from a bear trap that almost kills him.
Cheyenne is asked to talk to Chief Sitting Bull to calm the waters after his son is accused of killing a miner. A newspaperwoman forces her way onto the trip to interview Chief Sitting Bull and ends up starting an Indian uprising.